Abstract #1338

A Non-invasive Method for Quantifying Cerebral Blood Flow by Hybrid PET/MR

Tracy Ssali^1,2, Udunna Anazodo^1,2, Jonathan Thiessen^1,2, Frank Prato^1,2, and Keith St Lawrence^1,2

¹Lawson Health Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada

While PET with [¹⁵O]H₂O is the gold standard for imaging CBF, quantification requires measuring the arterial input function (AIF), which is an invasive and noisy procedure. ASL is an attractive alternative, however, its accuracy is limited by low SNR. Considering these limitations, we propose a hybrid PET/MRI approach using global CBF measurements from phase contrast MRI to convert [¹⁵O]H₂O PET data into CBF maps. To test this method, using a large animal model, CBF was measured by this hybrid approach and by PET only, where the AIF was measured. Good agreement was found over a CBF range (20-100 ml/100g/min).

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