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Abstract #1340

Improved clinical workflow for simultaneous whole-body PET/MRI using high-resolution CAIPIRINHA-accelerated MR-based attenuation correction

Martin T. Freitag1, Matthias Fenchel2, Philipp Bäumer1, Thorsten Heußer3, Christopher M. Rank3, Marc Kachelrieß3, Klaus Kopka4, Antonia Dimitrakopoulou-Strauss5, Frederik Giesel6, Uwe Haberkorn6, Klaus H. Maier-Hein7, Ralf Floca7, Mark E. Ladd3, Heinz-Peter Schlemmer1, and Florian Maier3

1Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Siemens Healthineers, Erlangen, Germany, 3Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Divison of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Germany, 5Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany, 7Junior Group Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany

The present study assesses the value and reproducibility of a novel CAIPIRINHA-accelerated T1-weighted Dixon-based prototype for whole-body PET/MRI in comparison to the clinical standard. This prototype allows the aquisition of an MR-based attenuation correction and a high-resolution T1w DIXON stack that may be used for diagnostic correlation of PET findings in one single step. Voxel-wise intra-individual differences, intermethod-agreement using regression and bland-altman plot analysis, inter-reader agreement for image quality and a repeated measurement experiment in a healthy volunteer without tracer injection were peformed. The novel prototype demonstrated a high reproducibility of standardized uptake value quantification compared to the standard and excellent image quality for all body regions. Smaller breathing artifacts in the lungs may transfer on the PET µmap and thus influence the attenuation correction. Therefore, physicians and the technicians need to assess the µmap to veriy artifact-free acquisition. The novel protoype is useful for clinical PET/MRI studies towards time-efficient protocols as a separate T1w-sequence may be omitted.

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