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Abstract #1344

Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer

Spencer T. Lake1, Kirsten L. Greene2, Antonio C. Westphalen1, Spencer C. Behr1, Ronald Zagoria1, Eric J. Small3, Peter R. Carroll2, and Thomas A. Hope1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Urology, UCSF, San Francisco, CA, United States, 3Medicine, Division of Hematology and Oncology, UCSF, San Francisco, CA, United States

On 68Ga-PSMA-11 PET/MRI for biochemically recurrent prostate cancer, small PSMA-positive lesions are detected on some, but not all MRI sequences. To determine the most effective sequences to obtain for a 68Ga-PSMA-11 PET/MRI protocol, the sensitivities of small FOV T2, T1 post-contrast, and diffusion-weighted sequences for identification of small abdominopelvic nodes were evaluated. In addition, multiphasic contrast-enhanced Differential Subsampling with Cartesian Ordering (DISCO) images were evaluated for detection of prostate bed recurrence. Examination of 48 consecutive patients indicates that small FOV T2 images are most sensitive for small abdominopelvic nodes and DISCO images are most sensitive for prostate bed recurrence.

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