Removing the estimation bias due to the noise floor in multi-parameter maps
Karsten Tabelow1, Chiara D'Alonzo1, Lars Ruthotto2, Martina F. Callaghan3, Nikolaus Weiskopf4, Joerg Polzehl1, and Siawoosh Mohammadi5
1WIAS, Berlin, Germany, 2Emory University, Atlanta, USA, 3Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 4Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Leipzig, Germany, 5Department of Systems Neuroscience, Medical Center Hamburg-Eppendorf, Hamburg, Germany
We demonstrate the bias effect due to the low signal-to-noise ratio of ultra-high resolution (0.5μm isotropic) Multi-Parameter Mapping acquisitions of quantitative R1, R2* and PD maps and develop a method for improved parameter estimation.
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