Abstract #1354

Removing the estimation bias due to the noise floor in multi-parameter maps

Karsten Tabelow¹, Chiara D'Alonzo¹, Lars Ruthotto², Martina F. Callaghan³, Nikolaus Weiskopf⁴, Joerg Polzehl¹, and Siawoosh Mohammadi⁵

¹WIAS, Berlin, Germany, ²Emory University, Atlanta, USA, ³Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Leipzig, Germany, ⁵Department of Systems Neuroscience, Medical Center Hamburg-Eppendorf, Hamburg, Germany

We demonstrate the bias effect due to the low signal-to-noise ratio of ultra-high resolution (0.5μm isotropic) Multi-Parameter Mapping acquisitions of quantitative R1, R2* and PD maps and develop a method for improved parameter estimation.

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