Abstract #1366

Comparison of Myelin Water Fractions from Multi-Echo Spin-Echo and Multi-Gradient Echo Techniques

Eva Alonso Ortiz¹, Ives R. Levesque^1,2, and G. Bruce Pike³

¹McGill University, Montreal, QC, Canada, ²Research Institute, McGill University Health Centre, Montreal, QC, Canada, ³University of Calgary, Calgary, AB, Canada

Myelin Water Fraction (MWF) imaging is typically achieved using a Multi-Echo Spin-Echo (MESE) sequence that has a long acquisition time. The Multi-Gradient Recalled Echo (MGRE) sequence on the other hand, is fast, has multi-slice and 3D imaging capabilities, high temporal sampling of the signal decay curve, and low SAR. In this study, we imaged 11 healthy volunteers using MESE and MGRE sequences to perform a method-comparison study for the MWF. Our results suggest that the MGRE approach to MWF imaging is highly promising.

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