Abstract #1371

Reproducibility Study of Direct and Non-Linear Inversion High-Resolution Magnetic Resonance Elastography (MRE) of the Hippocampus

Lucy V Hiscox^1,2, Mike Perrins², Curtis L Johnson³, Matt DJ McGarry^4,5, Eric Barnhill⁶, John Huston III⁷, Ingolf Sack⁶, Jürgen Braun⁶, Edwin JR van Beek², John M Starr¹, and Neil Roberts²

¹Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom, ²Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, ³Department of Biomedical Engineering, University of Delaware, ⁴Thayer School of Engineering, Dartmouth College, ⁵Department of Biomedical Engineering, Columbia University, ⁶Institute for Medical Informatics, Charité Universitätsmedizin Berlin, ⁷Department of Radiology, Mayo Clinic

Certain neurological disorders may not be detected with current clinical imaging modalities. Magnetic Resonance Elastography (MRE) combines acoustics with MRI to provide maps of tissue mechanical properties and may be sensitive to subtle tissue pathologies. Two published approaches for performing high-resolution MRE (so-called Direct Inversion and Non-Linear inversion) were applied to enable comparison of test-retest reproducibility of the hippocampus. Intraclass correlation coefficient found DI and NLI to display fair (0.42) and excellent (0.95) reproducibility, respectively, for measuring the magnitude of the complex shear modulus |G*|. Future work will assess the relative magnitude of technical and biological variance including both sex and ageing effects.

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