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Abstract #1375

In vivo cerebral MR elastography in a mouse model of Alzheimer’s disease: preliminary results

Shreyan Majumdar1 and Dieter Klatt1

1Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

In vivo magnetic resonance elastography (MRE) experiments on Alzheimer’s disease (AD) mouse model were conducted. The AD and Control mice were in the age group of 3-4 months (n = 4 for both). Median stiffness values for the overall mouse brain (central axial slices) and for the hippocampus region were calculated. No differences were observed between the two groups for the overall brain. For the hippocampus region, a trend of cerebral stiffness decrease in AD was measured. The small sample size did not allow for statistically significant conclusions. Further experiments are underway.

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