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Abstract #1417

Application of Iterative Reconstruction for MR Digital Subtraction Angiography: Toward Better Visualization of Small Vessels and Reduction of Gadolinium-Based Contrast Media.

Yasutaka Fushimi1, Tomohisa Okada2, Akira Yamamoto1, Tsutomu Okada1, Aurelien Stalder3, Christoph Forman3, Michaela Schmidt3, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Siemens Healthcare GmbH, Erlangen, Germany

Improved signal and temporal footprint for dynamic MRA due to the retrospective iterative reconstruction may better visualize small peripheral vessels with reduced GBCA dose. CE-MRA-TWIST images were reconstructed twice from the same raw data, with the standard product reconstruction and with iterative reconstruction (IT) by using L1 wavelet regularization in space and time. CE-MRA-IT-TWIST nicely visualized hemodynamics in the brain even with 20% GBCA dose administration compared with CE-MRA-TWIST, especially in the arterial phase. Enhancement slope of CE-MRA-IT-TWIST was statistically higher than that of CE-MRA-TWIST.

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