Abstract #1417

Application of Iterative Reconstruction for MR Digital Subtraction Angiography: Toward Better Visualization of Small Vessels and Reduction of Gadolinium-Based Contrast Media.

Yasutaka Fushimi¹, Tomohisa Okada², Akira Yamamoto¹, Tsutomu Okada¹, Aurelien Stalder³, Christoph Forman³, Michaela Schmidt³, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Siemens Healthcare GmbH, Erlangen, Germany

Improved signal and temporal footprint for dynamic MRA due to the retrospective iterative reconstruction may better visualize small peripheral vessels with reduced GBCA dose. CE-MRA-TWIST images were reconstructed twice from the same raw data, with the standard product reconstruction and with iterative reconstruction (IT) by using L1 wavelet regularization in space and time. CE-MRA-IT-TWIST nicely visualized hemodynamics in the brain even with 20% GBCA dose administration compared with CE-MRA-TWIST, especially in the arterial phase. Enhancement slope of CE-MRA-IT-TWIST was statistically higher than that of CE-MRA-TWIST.

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