MR image-guided radiotherapy (IGRT) holds potentials on outcome improvement in the head-and-neck (HN) radiotherapy. Patients receiving MR-guided multi-fractional HN IGRT are immobilized in each treatment fraction and set up to the exact position as of the treatment planning scan. Inter-fractional MR images are supposed to show highly correlated anatomy structure and edge information which can be incorporated into compressed sensing (CS) based MR reconstruction to shorten the scan time while preserve image quality in multiple fractions. In this study, we investigated the feasibility of accelerating high spatial resolution 3D MRI using CS with structure-guided total variation for multi-fractional HN radiotherapy.
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