Abstract #1426

Flexible Prospective Compressed Sensing Acceleration of Prostate DCE-MRI with Quantized CIRCUS

James A Rioux^1,2,3, Nathan J Murtha^1,3, Allister Mason³, Chris V Bowen^1,2,3,4, Sharon Clarke^1,2,3, and Steven D Beyea^1,2,3,4

¹Biomedical Translational Imaging Centre (BIOTIC), Nova Scotia Health Authority, Halifax, NS, Canada, ²Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ³Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, ⁴Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

Improving the temporal resolution of dynamic contrast-enhanced (DCE) MRI sequences often requires a reduction in image spatial resolution or quality. We propose an acquisition and reconstruction strategy, Quantized CIRCUS, which allows reconstruction of prospectively accelerated DCE-MRI data with desired spatial and temporal resolution, similar to golden-angle radial acquisition schemes but using Cartesian sampling. We demonstrate that this approach allows improved temporal resolution compared to standard clinical methods, without significant degradation of image quality or resolution, which may provide more accurate information for diagnosis of diseases like prostate cancer.

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