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Abstract #1426

Flexible Prospective Compressed Sensing Acceleration of Prostate DCE-MRI with Quantized CIRCUS

James A Rioux1,2,3, Nathan J Murtha1,3, Allister Mason3, Chris V Bowen1,2,3,4, Sharon Clarke1,2,3, and Steven D Beyea1,2,3,4

1Biomedical Translational Imaging Centre (BIOTIC), Nova Scotia Health Authority, Halifax, NS, Canada, 2Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 3Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, 4Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

Improving the temporal resolution of dynamic contrast-enhanced (DCE) MRI sequences often requires a reduction in image spatial resolution or quality. We propose an acquisition and reconstruction strategy, Quantized CIRCUS, which allows reconstruction of prospectively accelerated DCE-MRI data with desired spatial and temporal resolution, similar to golden-angle radial acquisition schemes but using Cartesian sampling. We demonstrate that this approach allows improved temporal resolution compared to standard clinical methods, without significant degradation of image quality or resolution, which may provide more accurate information for diagnosis of diseases like prostate cancer.

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