Abstract #1430

Evaluating effect of B1 field Inhomogeneity on DCE-MRI Data Analysis of Brain Tumor Patients at 3T

ANIRBAN SENGUPTA¹, RAKSHIT DADARWAL ¹, RAKESH KUMAR GUPTA², and ANUP SINGH^1,3

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Radiology, Fortis Memorial Research Institute, GURGAON, ³Biomedical Engineering, All India Institute Of Medical Science, New Delhi, India

In the current study, transmit B1 field inhomogeneity(B1FI) distribution and propagation of flip-angle(FA) related errors to Dynamic-contrast-enhanced(DCE) MRI data analysis in brain tumors of human subjects at 3T MRI were studied. Experimental and simulation studies were performed to evaluate the propagation of these errors to DCE-MRI data analysis and its correction were performed during signal intensity(S(t)) to concentration-time-curve(C(t)) conversion. This study show that B1FI introduced substantial errors in DCE-MRI data analysis(tracer-kinetic and hemodynamic parameters) and these errors were mitigated by correcting FA using B1 map. B1FI related error also showed dependence on concentration of contrast agent and length of concentration-time-curve.

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