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Abstract #1445

Bias and SNR of $$$T_1$$$ estimates derived from joint fitting of actual flip-angle and FLASH imaging data with variable flip angles

M. Dylan Tisdall1

1Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Previous work has suggested fitting joint AFI/FLASH data for T1 and B1+ by minimizing the 2-norm of the difference between the signal model and measurements will produce unbiased estimates of T1. We demonstrate that, contrary to previous results, the estimator has a substantial bias that varies with both the true T1 and B1+, and the receive channel count. We also demonstrate that the correct ML estimator removes the effect of channel count, and that the choice of AFI protocol has a larger impact of the quality of estimates than the addition of an extra FLASH scan.

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