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Abstract #1447

Harmonization for cortical thickness across sites in multi-center MRI study

Lin Zhao1, Tuo Zhang1, Xianjun Li2, Chao Jin2, Miaomiao Wang2, Xiaocheng Wei3, Hong Yin4, Zengjun Zhang5, Xiaoqun Yao6, Xiaoling Zhang7, and Jian Yang2

1Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, People's Republic of China, 2Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People's Republic of China, 3MR Research China, GE Healthcare, Beijing, People's Republic of China, 4Department of Radiology, Xijing Hospital, the Fourth Military University, Xi'an, People's Republic of China, 5Department of Diagnostic Radiology, Xi'an Children Hospital, Xi’an, People's Republic of China, 6Department of Radiology, Xi'an Gaoxin Hospital, Xi'an, People's Republic of China, 7CT MR Department, the People's Hospital of Shaanxi Province, Xi'an, People's Republic of China

Cerebral cortex encodes crucial information of brain development, cytoarchitecture and function. However, varying data acquisition conditions at different centers could hamper group-wisely statistical analysis. This study aims to test the consistency of cortical thickness in the human brain across four sites and harmonize the deviations. Our results showed that variation of cortical thickness across sites were regionally independent, and deviation across centers could be reduced by linear regression method at a global scale, while the variations across subjects were well preserved. Those results suggest that our method has the promise in harmonizing cortical thickness measures in multi-center study.

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