Abstract #1447

Harmonization for cortical thickness across sites in multi-center MRI study

Lin Zhao¹, Tuo Zhang¹, Xianjun Li², Chao Jin², Miaomiao Wang², Xiaocheng Wei³, Hong Yin⁴, Zengjun Zhang⁵, Xiaoqun Yao⁶, Xiaoling Zhang⁷, and Jian Yang²

¹Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, People's Republic of China, ²Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People's Republic of China, ³MR Research China, GE Healthcare, Beijing, People's Republic of China, ⁴Department of Radiology, Xijing Hospital, the Fourth Military University, Xi'an, People's Republic of China, ⁵Department of Diagnostic Radiology, Xi'an Children Hospital, Xi’an, People's Republic of China, ⁶Department of Radiology, Xi'an Gaoxin Hospital, Xi'an, People's Republic of China, ⁷CT MR Department, the People's Hospital of Shaanxi Province, Xi'an, People's Republic of China

Cerebral cortex encodes crucial information of brain development, cytoarchitecture and function. However, varying data acquisition conditions at different centers could hamper group-wisely statistical analysis. This study aims to test the consistency of cortical thickness in the human brain across four sites and harmonize the deviations. Our results showed that variation of cortical thickness across sites were regionally independent, and deviation across centers could be reduced by linear regression method at a global scale, while the variations across subjects were well preserved. Those results suggest that our method has the promise in harmonizing cortical thickness measures in multi-center study.

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