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Abstract #1475

Quantification of contrast agent-induced enhancement of brain lesions in multiple sclerosis

Jung-Jiin Hsu1, William A. Stern1, Jung-Yu C. Hsu2, and Roland G. Henry1

1Department of Neurology, University of California San Francisco, San Francisco, CA, United States, 2Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan

Contrast agents are routinely used in MRI to detect and evaluate tissue lesions. Conventional clinical protocols use T1-weighted sequences to visualize Gd contrast agent enhancement. Because T1-weighted MRI does not produce quantitative measurements, it is difficult to describe the lesion enhancement in quantitative terms and to infer the degree of the underlining disease activities of the lesions. A fast, whole-brain high-resolution T1 mapping method was developed to address this problem and applied to multiple sclerosis.

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