Abstract #1475

Quantification of contrast agent-induced enhancement of brain lesions in multiple sclerosis

Jung-Jiin Hsu¹, William A. Stern¹, Jung-Yu C. Hsu², and Roland G. Henry¹

¹Department of Neurology, University of California San Francisco, San Francisco, CA, United States, ²Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan

Contrast agents are routinely used in MRI to detect and evaluate tissue lesions. Conventional clinical protocols use T₁-weighted sequences to visualize Gd contrast agent enhancement. Because T₁-weighted MRI does not produce quantitative measurements, it is difficult to describe the lesion enhancement in quantitative terms and to infer the degree of the underlining disease activities of the lesions. A fast, whole-brain high-resolution T₁ mapping method was developed to address this problem and applied to multiple sclerosis.

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