There have been only few attempts to obtain maps of the diffusion properties of brain metabolites with diffusion weighted spectroscopic imaging. In this study we developed an echo planar based diffusion weighted spectroscopic imaging (DW-EPSI) method which uses a pairs of bipolar diffusion gradient to measure the apparent diffusion coefficient (ADC) of metabolites across an entire slice. The sequence was tested and validated on phantom and five healthy volunteers. The ADC values from DW-EPSI are in agreement with previous studies. The novel technique will enable a better understanding of the intracellular metabolism and water diffusivity correlates in pathologies.
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