Purpose: To develop a simple and cross-platform pulse sequence that meets the following criteria: 1) all directly acquired images are clinically useful, 2) achieves minimalistic scan times, and 3) leads to excellent image quality as well as accurate MS-qMRI mapping. Methods: Tri-FSE consists of a single-echo-FSE sequence that is run in temporal concatenation with a dual-echo FSE sequence that all together generate T1-, T2, and PD-weighted directly acquired images. Results: Tri-FSE was implemented at medium and high spatial resolution at 1.5T and 3.0T. Conclusion: Tri-FSE is a dual purpose simple pulse sequence that is useful for clinical and scientific purposes.
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