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Abstract #1532

Six-month follow-up of the patients with the low-grade femoral cartilage lesions using T2 mapping at 3 and 7 Tesla

Vladimir Juras1,2, Markus Schreiner1, Rahel Heule3, Pavol Szomolanyi1,2, Stefan Zbyn1,4, Vladimir Mlynarik1, Stefan Marlovits5, Didier Laurent6, Celeste Scotti6, Joerg Goldhahn6, Kubiak Ewa6, Haber Harry6, Ivan Frollo2, Oliver Bieri3, and Siegfried Trattnig1,7

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Imaging Methods, Slovak Academy of Sciences, Institute of Measurement Scinece, Bratislava 4, Slovakia, 3Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 4Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 5University Clinic for Trauma Surgery, Medical University of Vienna, Vienna, Austria, 6Novartis Institutes for Biomedical Research, Basel, 7CD Laboratory for Clinical Molecular MR Imaging

Transverse relaxation time (T2) maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in four time points (baseline, 8 days, 3 and 6 months). T2 mapping was based on a 3D triple echo steady state imaging sequence delivering high quality high-resolved T2 maps at ultra-high field MRI. The results showed opposite trends of T2 values at 3T (a decrease) and 7T (an increase) over time. The statistically significant difference was found in case of deep zone of the cartilage lesion at 3T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.

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