Abstract #1532

Six-month follow-up of the patients with the low-grade femoral cartilage lesions using T2 mapping at 3 and 7 Tesla

Vladimir Juras^1,2, Markus Schreiner¹, Rahel Heule³, Pavol Szomolanyi^1,2, Stefan Zbyn^1,4, Vladimir Mlynarik¹, Stefan Marlovits⁵, Didier Laurent⁶, Celeste Scotti⁶, Joerg Goldhahn⁶, Kubiak Ewa⁶, Haber Harry⁶, Ivan Frollo², Oliver Bieri³, and Siegfried Trattnig^1,7

¹Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Imaging Methods, Slovak Academy of Sciences, Institute of Measurement Scinece, Bratislava 4, Slovakia, ³Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, ⁴Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ⁵University Clinic for Trauma Surgery, Medical University of Vienna, Vienna, Austria, ⁶Novartis Institutes for Biomedical Research, Basel, ⁷CD Laboratory for Clinical Molecular MR Imaging

Transverse relaxation time (T2) maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in four time points (baseline, 8 days, 3 and 6 months). T2 mapping was based on a 3D triple echo steady state imaging sequence delivering high quality high-resolved T2 maps at ultra-high field MRI. The results showed opposite trends of T2 values at 3T (a decrease) and 7T (an increase) over time. The statistically significant difference was found in case of deep zone of the cartilage lesion at 3T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.

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