Abstract #1550

A prospective natural history study on cartilage composition changes in patients with low-grade cartilage injury

Didier Laurent¹, Vladimir Juras², Vladimir Mlynarik², Markus Schreiner², Pavol Szomolanyi², Stefan Zbyn^2,3, Celeste Scotti¹, Joerg Goldhahn⁴, Harry Haber¹, Ewa Kubiak¹, Ronenn Roubenoff¹, Stefan Marlovits⁵, and Siegfried Trattnig²

¹Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, ²Biomedical Imaging and Image-guided therapy, Medical University of Vienna, Vienna, Austria, ³Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ⁴Institutes for Biomechanics, ETH, Zurich, Switzerland, ⁵Traumatology, Medical University of Vienna, Vienna, Austria

Changes in the macromolecular structure of articular cartilage were monitored in patients with a low-grade cartilage defect by using a comprehensive, compositional MRI approach over a period of 6 months. Preliminary results showed that, while no large change in glycosaminoglycan contents was observed, the bi-layer structure bound to the collagen fiber organization may have been further deteriorated over time.

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