Meeting Banner
Abstract #1550

A prospective natural history study on cartilage composition changes in patients with low-grade cartilage injury

Didier Laurent1, Vladimir Juras2, Vladimir Mlynarik2, Markus Schreiner2, Pavol Szomolanyi2, Stefan Zbyn2,3, Celeste Scotti1, Joerg Goldhahn4, Harry Haber1, Ewa Kubiak1, Ronenn Roubenoff1, Stefan Marlovits5, and Siegfried Trattnig2

1Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, 2Biomedical Imaging and Image-guided therapy, Medical University of Vienna, Vienna, Austria, 3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 4Institutes for Biomechanics, ETH, Zurich, Switzerland, 5Traumatology, Medical University of Vienna, Vienna, Austria

Changes in the macromolecular structure of articular cartilage were monitored in patients with a low-grade cartilage defect by using a comprehensive, compositional MRI approach over a period of 6 months. Preliminary results showed that, while no large change in glycosaminoglycan contents was observed, the bi-layer structure bound to the collagen fiber organization may have been further deteriorated over time.

This abstract and the presentation materials are available to members only; a login is required.

Join Here