Abstract #1567

Magnetic resonance biomarkers for cachexia in a mouse model of pancreatic ductal adenocarcinoma.

Ravneet S Vohra¹, Matthew Campbell¹, Joshua Park¹, Kayla Gravelle², Stella wHang², Yak-Nam Wang², Joo-Ha Hwang³, David Marcinek¹, and Donghoon Lee¹

¹Department of Radiology, University of Washington, Seattle, WA, United States, ²Center for Industrial and Medical Ultrasound Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Department of Medicine, University of Washington, Seattle, WA, United States

Cancer induced cachexia is prevalent with many cancers and is characterized by loss of muscle and fat mass. In pancreatic cancer the syndrome affects approximately 80% of patients. Non-invasive multi-parametric MRI was used to monitor the progression of cachexia in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC). Using pixel-by-pixel comparison, we demonstrate a significant decrease in skeletal muscle T₂ and increase in magnetization transfer ratio (MTR). Additionally, we found significant difference in diffusion parameters.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.