Cancer induced cachexia is prevalent with many cancers and is characterized by loss of muscle and fat mass. In pancreatic cancer the syndrome affects approximately 80% of patients. Non-invasive multi-parametric MRI was used to monitor the progression of cachexia in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC). Using pixel-by-pixel comparison, we demonstrate a significant decrease in skeletal muscle T2 and increase in magnetization transfer ratio (MTR). Additionally, we found significant difference in diffusion parameters.