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Abstract #1571

Changes in muscle morphometry, composition and performance in patients with sporadic inclusion body myositis

Didier Laurent1, Jonathan Riek2, Christopher DJ Sinclair3, John S. Thornton3, Ronenn Roubenoff1, Dimitris A. Papanicolaou4, Parul Houston5, Tarek Yousry3, Pedro M. Machado3, and Michael G. Hanna3

1Novartis Institutes for Biomedical Research, Basel, Switzerland, 2VirtualScopics, LLC, Rochester, NY, United States, 3MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, United States, 5Novartis Pharma AG, Basel, Switzerland

A comprehensive MRI approach was used to characterize changes in muscle structure and composition in patients with sporadic inclusion body myositis (sIBM) over 1-year. Results showed progressive deterioration in muscle quality, e.g. increased connective tissue volume in the most affected muscles, and this appeared to be associated with a functional impact.

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