Abstract #1571

Changes in muscle morphometry, composition and performance in patients with sporadic inclusion body myositis

Didier Laurent¹, Jonathan Riek², Christopher DJ Sinclair³, John S. Thornton³, Ronenn Roubenoff¹, Dimitris A. Papanicolaou⁴, Parul Houston⁵, Tarek Yousry³, Pedro M. Machado³, and Michael G. Hanna³

¹Novartis Institutes for Biomedical Research, Basel, Switzerland, ²VirtualScopics, LLC, Rochester, NY, United States, ³MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, United States, ⁵Novartis Pharma AG, Basel, Switzerland

A comprehensive MRI approach was used to characterize changes in muscle structure and composition in patients with sporadic inclusion body myositis (sIBM) over 1-year. Results showed progressive deterioration in muscle quality, e.g. increased connective tissue volume in the most affected muscles, and this appeared to be associated with a functional impact.

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