Abstract #1585

Simultaneous measurement of muscle transverse relaxation rates of R2, R2' and R2*: application in unilateral femoral artery embolization

Chengyan Wang¹, Rui Zhang², Bihui Zhang³, Haochen Wang³, Xiaodong Zhang⁴, Min Yang³, Jue Zhang^1,2, Xiaoying Wang^1,4, and Jing Fang^1,2

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, ²College of Engineering, Peking University, Beijing, People's Republic of China, ³interventional radiology and vascular surgery, Peking University First Hospital, Beijing, People's Republic of China, ⁴Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China

Diagnosis of the ischemic lesion is challenging and often requires the use of pharmaco-mechanical methods. This study demonstrates the feasibility of using a susceptibility-based MRI technique with the multi-echo gradient and spin echo (MEGSE) sequence to assess the skeletal muscle oxygenation alternations in animal model of unilateral femoral artery embolization. The results shown that the skeletal muscle R2 decreases obviously from after femoral artery embolization, while R2’ increases correspondingly. MEGSE seems to be an appropriate method for the evaluation of skeletal muscle ischemia after embolization.

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