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Abstract #1606

Fat Fraction Histogram Analysis: Insights into the Biology of Lipomatous Tumors

Mikael Skorpil1,2, Henric Rydén3, Elisabet Lidbrink4, Otte Brosjö5, and Johan Berglund6,7

1Department of Radiation Sciences, Umeå University, Umeå, Sweden, 2Department of Radiology, Uppsala, Sweden, 3Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, 4Department of Oncology and Pathology, Karolinska Institute and Karolinska University Hospital, Solna, Sweden, 5Department of Orthopaedic Surgery, Karolinska University Hospital, Solna, Sweden, 6Department of Medical Radiation Physics, Karolinska University Hospital, Stockholm, Sweden, 7Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden

Fat content evaluation in soft-tissue tumors is based on visual grading of T1-weighted images with uncertain accuracy and inter-rater variability. We used a multi-point Dixon technique to quantitatively measure the distribution of proton density fat fraction in different lipomatous tumors. The effect of radiotherapy on fat content in a myxoid liposarcoma was also assessed, with histograms revealing a distinct alteration. Our data give supporting evidence that maturation of tumor cells is the cause for the lipoma-like areas seen after radiotherapy of myxoid liposarcomas. On a voxel level (2×2×2 mm3) various lipomatous tumors exhibited different fat fraction histograms.

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