Meeting Banner
Abstract #1610

Ultrashort Echo Time Chemical Shift Quantitative Susceptibility Mapping (UTE-CS-QSM) for Hemosiderin Assessment in Hemophilic Arthropathy

Xing Lu1,2, Annette von Drygalski3, Alexey Dimov4, Lena Volland3, Zhe Liu4, Yi Wang4, Jiang Du1, and Eric Y Chang1,5

1Department of Radiology, University of California, San Diego, CA, United States, 2Institute of Electrical Engineering, Chinese Academy of Science, Beijing, People's Republic of China, 3Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, CA, United States, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 5Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Hemosiderin deposition in hypertrophic synovium is a hallmark of progressive hemophilic arthropathy and accumulates with joint bleeding. . Conventional quantification of hemosiderin uses semi-quantitative MRI scores, assigning grades of small, moderate, or large to assess the burden of hemosiderin. To date, there is no known method to assess or quantify hemosiderin concentration within synovium due to the extremely short T2 values of this tissue. In this pilot study, we demonstrated that the clinically compatible IDEAL UTE-CS-QSM technique can be used to quantify hemosiderin depositions. We have shown that synovium in joints with hemophilic arthropathy demonstrates various susceptibility values, likely corresponding to different concentrations of hemosiderin.

This abstract and the presentation materials are available to members only; a login is required.

Join Here