The deposition of metal particles near total joint replacements has substantial impact on patient morbidity. Current standards of clinical management of patients with symptomatic total hip replacements are highly leveraged on the presence of wear debris in periprosthetic tissues. Our group has recently developed methods to perform off-resonance based identification of metal particle deposits. Here, we provide analysis on the source of tissue-based metal particle Larmor frequency offsets. The results of this analysis provide new insight on the role of off-resonance observables in the progression of symptomatic failed total hip replacements.