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Abstract #1626

Echo-time optimization in Spin Echo EPI fMRI using BOLD-sensitivity models and hypercapnic manipulation at 3T

Don Marcial Ragot1,2 and Jean Chen1,2

1Dept. of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute, Toronto, ON, Canada

The preferred echo-time (TE) used in most spin-echo EPI (SE-EPI) fMRI studies is approximately the tissue T2 value (65–100ms at 3 T). In this study, we use a hypercapnia paradigm with SE-EPI and three metrics of BOLD-sensitivity to model the TE that maximizes BOLD detection at 3 T. We concluded that while the maximal absolute BOLD contrast occurs near tissue T2 (~75ms), a TE of 55ms both maximizes tissue CNR and minimizes BOLD effects from non-neuronal sources.

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