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Abstract #1642

Group differences in default mode network connectivity not just anti-correlation depend on choice of nuisance regressor model

William J Cottam1,2,3 and Dorothee P Auer1,2,3

1Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 2Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Resting state fMRI is prone to a large range of factors affecting the acquired data and processing pipelines available, which can impact on the outcome of a study. This study assessed the similarity of time series taken from aCompCor outputs to global signal to assess the inclusion of a ‘proxy’ global signal and its effect on group-wise tests of default-mode connectivity. The first components of both white matter and CSF were highly correlated with global signal and regressing either global signal or aCompCor outputs altered group-comparisons of functional connectivity. Future studies should scrutinise and report their postprocessing pipelines clearly.

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