Meeting Banner
Abstract #1663

Measurements of the flow component of the hemodynamic response function in human cerebral cortex

David Ress1 and JungHwan Kim1

1Neuroscience, Baylor College of Medicine, Houston, TX, United States

Brief cortical neural activity creates changes in local blood flow and oxygen uptake. Functional magnetic resonance imaging can measure this neurovascular coupling as a blood oxygen level dependent (BOLD) signal. The BOLD response to brief stimulation is termed the hemodynamic response function (HRF). We developed a computational model for the BOLD HRF, which predicts that the flow component of the HRF is a simple underdamped sinusoid. To test this prediction, we used arterial spin labeling to measure both CBF and BOLD responses in human cortex with high spatial and temporal resolution. Results confirm a significant flow undershoot in five subjects.

This abstract and the presentation materials are available to members only; a login is required.

Join Here