Abstract #1668

A novel role of intrinsic astrocytic calcium spikes to mediate brain states through central/dorsal thalamic nuclei

Maosen Wang^1,2, Yi He^1,2, and Xin Yu¹

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany

The astrocytic Ca²⁺ signal could be simultaneously acquired with either BOLD-fMRI or LFP signal in the rat cortex under anesthesia. Intrinsic astrocytic Ca²⁺ bursts spikes were detected in the cortex with suppressed spontaneous LFP and negative BOLD fMRI signal. These astrocytic Ca²⁺ spike events were different from the normal activity-evoked Ca²⁺ signal and also differentiate themselves from the lesion/stimulation-induced large-scale depolarization or spreading depression given the instantaneous whole-brain pattern and correlation with the thalamic LFP. The intrinsic astrocytic Ca²⁺ spike may mediate the brain states through the arousal thalamic pathway.

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