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Abstract #1685

Growing Apart or Growing Together: a Novel “Developing Triple Network” Hypothesis for Baby Connectome Study

Han Zhang1, Weiyan Yin2, Weili Lin1, and Dinggang Shen1,3

1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Department of Biomedical Engineering and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, Republic of

For baby connectome study, we propose a “developing triple network” model based on our findings from precious longitudinal infant resting-state fMRI data, which extends previous “triple network model” to 0-2 years old, a pivotal period which we have little knowledge on. Our developmental model provides future study with key information on early functional connectivity. We found medial prefrontal area is growing apart and its long-range FC is growing together at different speeds in the first 2 years. We, for the first time, found a novel early developmental pattern with both local and long-range FC increases at 6-9 months but decreases afterwards, indicating pivotal neural pruning mechanism from system neuroscience view point.

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