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Abstract #1690

Spatio-temporal extent of spontaneous and sensory evoked neural network activity.

Miriam Schwalm1, Felipe Aedo-Jury1, Florian Schmid2, Lydia Wachsmuth2, Andrea Kronfeld1, Hendrik Backhaus1, Cornelius Faber2, and Albrecht Stroh1

1Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany, 2Department of Clinical Radiology, University of M√ľnster, Nordrhein-Westfalen, Germany

Preclinical functional Magnetic Resonance Imaging in rodents has become a vital research tool for observing functional network connectivity at rest or during sensory stimulation. There is an ongoing debate about the differential effects of anesthesia on cortical connectivity, since functional connectivity networks fluctuate depending on global brain state. We analyzed the spontaneous and sensory evoked BOLD signal in rats during different network states induced by Isoflurane and Medetomidine anesthesia, finding them to lead to fundamentally different cortical connectivity. These results are crucial for interpreting rodent studies in the framework of translational resting state research including awake human data.

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