Functional T1 relaxation in the rotating frame (fT1ρ) is a new method of functional imaging that is thought to reflect changes in brain metabolism due to pH. FT1ρ may provide a more direct measurement of neuronal activity than the blood-oxygen level dependent (BOLD) contrast that is typically used for functional imaging. Here we applied both methods in order to study brain activation during a flashing checkerboard paradigm in participants with bipolar disorder as compared to controls. Linear mixed effect regression modeling revealed decoupling between the two imaging modalities in bipolar disorder in several brain regions.
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