Individuals infected with HIV frequently have HIV-associated neurocognitive disorders (HAND), despite effective plasma viral suppression. Various resting state networks studied with fMRI have been shown to be attenuated in HIV compared to seronegative controls. This study shows an increased connectivity in HIV subjects between the cerebellar vermis and bilateral insulae. Using clinical correlates, we conclude that this increased connectivity may be due to decreased efficiency in functional connectivity in the HIV-infected brain.
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