Abstract #1708

Altered Functional Connectivity in Essential Tremor Patients immediately following Thalamotomy using MRI guided Focused Ultrasound

Li Jiang¹, Jiachen Zhuo¹, Prashant Raghavan², Dheeraj Gandhi², Elias R. Melhem², and Rao Gullapalli¹

¹Center for Metabolic Imaging & Therapeutics, Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore School of Medicine, Baltimore, MD, United States, ²Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore School of Medicine, Baltimore, MD, United States

Essential tremor (ET) is a common neurological disorder. It is often characterized by progressive tremor of the arms or hands during voluntary movements. Ablation of the ventralis intermedius nucleus (VIM) of thalamus appears to be an effective treatment for ET. However, little is known regarding changes in the brain networks among ET patients and even less regarding the network changes following the thalamotomy. This study used resting state fMRI to investigate the changes in functional connectivity (FC) in brain networks immediately after the thalamotomy and reveals reduced FC between the ablated VIM and the motor cortex and cerebellum.

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