Although substantial efforts have been made to elucidate the neuronal basis of both refractory MDD (rMDD) and nonrefractory MDD (nrMDD), the results are inconsistant. We apply the resting-state dynamic functional connectivity (D-RSFC) to explore the divergence of neuroal basis between rMDD and nrMDD. Our results demonstrated that the D-RSFC method can well reveal the dysfunctional brain networks in the MDD. The prefrontal-limbic circuit is the most stable dysfunctional brain network in both MDD subtypes. Additionally, we speculate that the OFC-sgACC circuit, especially the frontal part of the left OFC-sgACC circuit, might be the biomarker for evaluating treatment response in MDD.