Abstract #1713

Effects of Lithium on resting-state fMRI in HIV-associated neurocognitive disorder

Yuchuan Zhuang¹, Madalina Tivarus², Eric H. Decloedt^3,4, John A. Joska⁵, Jianhui Zhong², and Giovanni Schifitto⁶

¹Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ²Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, ³Department of Medicine, Stellenbosch University, South Africa, ⁴Department of Medicine, University of Cape Town, South Africa, ⁵Department of Psychiatry and Mental Health, University of Cape Town, South Africa, ⁶Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States

This study firstly tested adjunctive lithium therapy in HIV patients with HAND. We examined the lithium effect using resting-state fMRI, and functional connectivity, amplitude of low-frequency fluctuation(ALFF) and fractional ALFF were calculated. We found significantly decrease of low-frequency oscillation and functional connectivity in lithium-treated group compared to placebo group, while neurocognitive performance was not different between the two groups.

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