Abstract #1715

fMRI and spectroscopic characterization of sensory and pain processing in “pain-free” mice

Giovanna Diletta Ielacqua¹, Aileen Schroeter¹, Aline Seuwen¹, David Buehlmann^1,2, Jael Xandry³, John N. Wood⁴, and Markus Rudin^1,3

¹Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, ²Neuroscience Center Zurich, Zurich, Switzerland, ³Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, ⁴Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom

FMRI has been widely used to assess changes in brain activity evoked by innocuous and noxious stimuli. However, stimulus-evoked fMRI (se-fMRI) measurements in mice have turned out challenging, and it is still under investigation whether and under which conditions se-fMRI applications in mice can lead to reliable readouts. Generally, se-fMRI could be a useful tool to characterize genetically modified mouse strains, such as mice exhibiting altered nociception. In this study, NaV1.7fl/fl:AdvCre mice were characterized with respect to neural processing of different types of peripheral stimuli and compared to a wildtype control group. Results of behavioral tests are compared to outcomes of fMRI and spectroscopic measurements.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.