Abstract #1718

Enhanced striatum connectivity is irrelevant to baseline perfusion in major depressive disorder following sertraline treatment

Changwei W. Wu^1,2, Zi-Xuan Chang³, I-Ling Chung⁴, Chien-Yuan Lin⁵, Ching-Po Lin⁶, Chi-Bin Yeh⁷, and Hong-Wen Kao⁴

¹Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan, ²Brain and Consciousness Research Center, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan, ⁴Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ⁵GE Healthcare, Taipei, Taiwan, ⁶Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, ⁷Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

We revisited the sertraline treatment effect on RSFC in drug-naïve MDD patients and evaluated the association between RSFC, ALFF and baseline CBF level. Twenty-four unmedicated MDD subjects were recruited and treated with sertraline for 6 weeks. Results showed negative correlation between HAM-D scores and striatum-MPFC RSFC. However, the therapeutic effect on RSFC was irrelevant to the CBF or ALFF levels, implying better temporal synchronizations from the neural basis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.