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Abstract #1729

Functional magnetic resonance imaging shows network activation from a non-visual light stimulus of deep brain photoreceptors in songbirds

Bruce Langford1, Thomas Neuberger2,3, Nanyin Zhang2,4, and Paul Bartell1,5

1Department of Animal Science, The Pennsylvania State University, University Park, PA, United States, 2Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States, 3Huck Institutes of the Life Sciences, The Pennsylvania State University, 4The Neuroscience Program, The Huck Institutes of Life Sciences, 5Interdepartmental Graduate Program in Neuroscience

Many avian species go through circannual changes in reproductive organs. Seasonal changes are triggered by non-visual photostimulation, made possible by the existence of nuclei with containing opsin channels. Photoactivation occurs when photosensitive neurons are stimulated, resulting in a cascade of activity in the brain, which initiates gonadal growth. Photorefraction is on a time-scale much longer than an experiment. We used echo planar imaging fMRI with a laser for stimulation and performed independent component analysis on each phase (before, during, and after stimulation). Network activation patterns differ in each phase.

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