Abstract #1734

White Matter Structural Differences among Subjects with Obstructive Sleep Apnea after Persistent CPAP-Treatment: A Non-Gaussian Diffusion MR Study with TBSS

Jiaxuan Zhang^1,2, Terri E. Weaver³, Zheng Zhong^1,4, Robyn A. Nisi³, Kelly R. Martin³, M. Muge Karaman¹, and Xiaohong Joe Zhou^1,5

¹Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China, ³College of Nursing, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁵Departments of Radiology, Neurosurgery, and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Obstructive sleep apnea (OSA) can result in brain white matter (WM) injuries due to the hypoxic exposure. Continuous positive airway pressure (CPAP) is a common method for treating OSA patients. However, it is unclear why some patients respond to the treatment whereas others do not. In this study, we employ a non-Gaussian diffusion MRI method using a continuous-time random-walk (CTRW) model with TBSS analysis to investigate the WM microstructural variations among OSA patients who responded differently to identical CPAP-treatment. Our results have shown that CTRW-related parameters in some WM tracts exhibited significant difference between the responders and non-responders.

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