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Abstract #1761

Multi-Spherical Diffusion MRI: An in-vivo Test-Retest Study of Time-Dependent q-space Indices

Rutger Fick1, Alexandra Petiet2, Mathieu Santin2, Anne-Charlotte Philippe2, Stephane Lehericy2, Rachid Deriche1, and Demian Wassermann1

1Universite Cote d'Azur, Inria, France, Sophia Antipolis, France, 2CENIR, Institut du Cerveau et de la Moelle epineere, Paris, France

Effective representation of the diffusion signal's dependence on diffusion time is a sought-after challenge in diffusion MRI (dMRI). As a solution, we recently proposed Multi-Spherical Diffusion MRI (MS-dMRI) to represent the dMRI signal in this four-dimensional space - varying over gradient strength, direction and diffusion time. Our representation allows for the estimation of time-dependent q-space features, providing unique insights on the tissue microstructure. In the study, we assess test-retest reproducibility of these indices in three C57Bl6 wild-type mice. We find that due to our effective regularization methodology during signal fitting, these time-dependent features can be estimated reliably without overfitting the data.

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