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Abstract #1767

Fast Linear Fitting of Bi-Exponential Intra-Voxel Incoherent Motion (IVIM) Models

Eric Thomas Peterson1, Natalie May Zahr2,3, Edith Vioni Sullivan2, and Adolf Pfefferbaum1

1Biosciences, SRI International, Menlo Park, CA, United States, 2Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States, 3Bioscience, SRI International, Menlo Park, CA, United States

This work introduces an extremely fast (whole image in ~5s) IVIM fitting procedure based on two sequential linear fits and demonstrates that it is comparable to the more traditional but much slower non-linear fitting. This method is valuable because current fitting methods typically take a significant amount of time, typically from minutes to hours, due to their iterative and non-linear nature. Therefore, this technique can be used as a fitting method alone and also as a way to seed more advanced techniques with accurate starting values.

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