It is challenging to diagnostically distinguish tumefactive demyelinating lesions (TDLs) from tumors surrounded by massive edema and mid-line shift such as high grade gliomas. We demonstrate free water diffusion MRI analysis to identify water diffusivity compartments in the lesion, and to monitor effects of medical treatment over time. We believe that free water diffusion analysis can be important adjunct to conventional MR, and adds value by improving our understanding of the histologic components of a lesion, which can help clinical diagnosis and potentially avoid biopsy.
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