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Abstract #1803

Individualized prediction of mild cognitive impairment based on patterns of altered tract integrity over the whole brain using diffusion spectrum imaging

Yu-Jen Chen1, Yun-Chin Hsu1, Yu-Ling Chang2, Ming-Jang Chiu3, and Wen-Yih Isaac Tseng1,4

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Psychology, National Taiwan University, Taipei, Taiwan, 3Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, 4Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

In this study, we tested the capability of individualized prediction for mild cognitive impairment (MCI) by using the information of whole brain tract integrity produced by tract-based automatic analysis method. The information was trained to search the tract segments that could most accurately separate the MCI patients and healthy participants. The optimal tract segments were searched with the area under receiver operating characteristic curve of 0.76. These specific segments of white matter tracts could potentially serve as imaging biomarker for predicting patients with MCI.

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