Abstract #1803

Individualized prediction of mild cognitive impairment based on patterns of altered tract integrity over the whole brain using diffusion spectrum imaging

Yu-Jen Chen¹, Yun-Chin Hsu¹, Yu-Ling Chang², Ming-Jang Chiu³, and Wen-Yih Isaac Tseng^1,4

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Psychology, National Taiwan University, Taipei, Taiwan, ³Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, ⁴Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

In this study, we tested the capability of individualized prediction for mild cognitive impairment (MCI) by using the information of whole brain tract integrity produced by tract-based automatic analysis method. The information was trained to search the tract segments that could most accurately separate the MCI patients and healthy participants. The optimal tract segments were searched with the area under receiver operating characteristic curve of 0.76. These specific segments of white matter tracts could potentially serve as imaging biomarker for predicting patients with MCI.

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