In this work, we introduce a high-resolution acquisition strategy for IVIM brain imaging using generalized Slider Simultaneous MultiSlice (gSlider-SMS) diffusion MRI. An SNR efficient multi b-value 10 simultaneous slice acquisition was used to obtain IVIM parameter maps with submillimeter isotropic resolution. Compared to a conventional acquisition (2 mm isotropic), high resolution IVIM provided improved delineation of the cortex and reduced partial volume contamination with CSF. Cortical perfusion measurements using the standard acquisition were falsely elevated by approximately 40% compared to gSlider-SMS IVIM. High resolution IVIM may provide more reliable perfusion information for evaluation of cortically based pathology.
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