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Abstract #1846

Diffusion Diffraction Inside Out

Valerij G Kiselev1, Alexander Ruh1, and Bibek Dhital1

1Dpt of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Diffusion diffraction, a famous result on NMR in porous media founds little application to in-vivo MRI. Beyond the high technical requirements, the reason can be seen in the principal limitations of this technique. It probes the shape of identical closed pores, which are not typical in-vivo. In this work, we generalize diffusion diffraction for an infinite connected compartment outside impermeable inclusions such as space external to biological cells with low membrane permeability. The signal at high diffusion weighting is expressed in terms of the inclusions' correlation function. The developed theory is supported by experiments in aqueous suspension of polystyrene microbeads.

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