Abstract #1852

Shortening acquisition time and increasing resolution to (1 mm)³ isotropic in 7T diffusion MRI (dMRI) still allows resolving fiber orientations and fiber crossings: a step towards clinical applications?

Ralf Lützkendorf¹, Robin M Heidemann², Sebastian Baecke¹, Michael Luchtmann³, Jörg Stadler⁴, Thorsten Feiweier², Jörn Kaufmann⁵, and Johannes Bernarding¹

¹Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany, ²Siemens Healthcare GmbH, Erlangen, Germany, ³Neurosurgery, University of Magdeburg, Magdeburg, Germany, ⁴Leibniz Institute for Neurobiology, Magdeburg, Germany, ⁵Neurology, University of Magdeburg, Magdeburg, Germany

Prior results in single-shot diffusion weighted EPI indicated that voxel sizes below (1.4mm)3 prohibit reliable resolution of fiber orientations and fiber crossings. Here we compare zoomed single-shot EPI with (1mm)³ isotropic resolution with readout-segmented EPI with (1.4mm)³ and (1.0mm)³ isotropic at ultra-high field strength of 7 Tesla. In all cases, fiber density orientation maps could be determined reliably thus enabling a resolution of main fiber directions and crossings even at (1mm)³ resolution.

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