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Abstract #1852

Shortening acquisition time and increasing resolution to (1 mm)³ isotropic in 7T diffusion MRI (dMRI) still allows resolving fiber orientations and fiber crossings: a step towards clinical applications?

Ralf Lützkendorf1, Robin M Heidemann2, Sebastian Baecke1, Michael Luchtmann3, Jörg Stadler4, Thorsten Feiweier2, Jörn Kaufmann5, and Johannes Bernarding1

1Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Neurosurgery, University of Magdeburg, Magdeburg, Germany, 4Leibniz Institute for Neurobiology, Magdeburg, Germany, 5Neurology, University of Magdeburg, Magdeburg, Germany

Prior results in single-shot diffusion weighted EPI indicated that voxel sizes below (1.4mm)3 prohibit reliable resolution of fiber orientations and fiber crossings. Here we compare zoomed single-shot EPI with (1mm)³ isotropic resolution with readout-segmented EPI with (1.4mm)³ and (1.0mm)³ isotropic at ultra-high field strength of 7 Tesla. In all cases, fiber density orientation maps could be determined reliably thus enabling a resolution of main fiber directions and crossings even at (1mm)³ resolution.

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