In this study，we aim to study the morphologic and micro-hemodynamic changes of MS plaques using SWI and DSC-PWI. We selected twenty-one MS patients diagnosed by the McDonald criteria (Revised Edition 2010) underwent MR scans including SWI and dynamical susceptibility contrasted MR perfusion weighted imaging (DSC-PWI) at baseline. Then Results were obtained by follow-up and scan. The MS plaques shows decreased phase value and blood perfusion. The characteristic of MS plaque is hypointense foci with small veins and only “abnormal vessels” region predict early changes.