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Abstract #1887

Improved reproducibility of longitudinal renal ASL perfusion measurements in children with chronic kidney disease using retrospective motion correction

Fabio Nery1, Enrico De Vita2,3, Chris A. Clark1, Isky Gordon1, and David L. Thomas3

1UCL Great Ormond Street Institute of Child Health, Developmental Imaging and Biophysics Section, London, United Kingdom, 2National Hospital for Neurology and Neurosurgery, Lysholm Department of Neuroradiology;, 3UCL Institute of Neurology, Department of Brain Repair and Rehabilitation

Arterial spin labelling (ASL) is a unique MR approach for quantifying tissue perfusion non-invasively. However, it is prone to motion-related artefacts which limit its application in the clinical domain, especially outside the brain. In this work, we combine a motion-insensitive ASL acquisition scheme with a specifically tailored retrospective motion correction pipeline. This enabled repeatable renal perfusion measurements to be obtained in the first ASL study in paediatric patients with moderate/severe chronic kidney disease.

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