Meeting Banner
Abstract #1907

Quantitative DCE-MRI Analysis using a Reference Tissue and AIF Tail

Zaki Ahmed1 and Ives Levesque1,2

1Medical Physics Unit, McGill University, Montreal, QC, Canada, 2Research Institute of the McGill University Health Centre, QC, Canada

The reference region model can quantify tumour perfusion without needing an arterial input function (AIF) and provides relative estimates, i.e. KTrans/KTrans,RR and ve/ve,RR which are usually converted to absolute KTrans and ve by using literature-based values for KTrans,RR and ve,RR. However, this approach fails to account for inter-patient variability. This study proposes a method that uses the Reference Region and AIF Tail (RRIFT) to estimate patient-specific KTrans,RR and ve,RR. The AIF tail is the post-peak part of the AIF and is easier to measure than the complete AIF. Evaluation in simulation and in-vivo showed that RRIFT provides comparable results to Tofts model, and even outperforms the Tofts model at slower temporal resolutions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here