The reference region model can quantify tumour perfusion without needing an arterial input function (AIF) and provides relative estimates, i.e. KTrans/KTrans,RR and ve/ve,RR which are usually converted to absolute KTrans and ve by using literature-based values for KTrans,RR and ve,RR. However, this approach fails to account for inter-patient variability. This study proposes a method that uses the Reference Region and AIF Tail (RRIFT) to estimate patient-specific KTrans,RR and ve,RR. The AIF tail is the post-peak part of the AIF and is easier to measure than the complete AIF. Evaluation in simulation and in-vivo showed that RRIFT provides comparable results to Tofts model, and even outperforms the Tofts model at slower temporal resolutions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords