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Abstract #1938

Relaxation Times and Magnetic Susceptibility of Human Umbilical Cord Blood at 3 Tesla

Sharon Portnoy1, Natasha Milligan2, Mike Seed3,4, John G. Sled1,5, and Christopher K. Macgowan1,6

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, ON, Canada, 3Department of Pediatrics and Diagnostic Imaging, University of Toronto, Toronto, ON, Canada, 4Division of Cardiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, 6Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada

With an increasing proportion of fetal cardiovascular MRI scans being performed at 3 Tesla, there is growing need for an accurate calibration, which characterizes relationships between MRI properties (T1, T2, susceptibility) and blood properties (oxygen-saturation, sO2 and hematocrit, Hct) at 3T. Accordingly, relaxometry measurements were performed at 3T on cord blood specimens (N=89) with a broad range of hematocrits (0.09<Hct<0.82) and oxygen-saturations (7%<sO2<100%). We also measured fetal blood susceptibility, which, to our knowledge, has never been reported. The data were effectively described by a simple, two-compartment model for blood.

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